Sadaf Farooqi is a Welcome Principal Research Fellow and Professor of Metabolism and Medicine at the University of Cambridge, UK. She is an internationally leading Clinician Scientist who has made seminal contributions to understanding the genetic and physiological mechanisms that underlie obesity and its complications. The work of Sadaf Farooqi and her colleagues has fundamentally altered the understanding of how body weight is regulated. With colleagues, she discovered and characterised the first genetic disorders that cause severe childhood obesity and established that the principal driver of obesity in these conditions was a failure of the control of appetite. Her work is often cited as an exemplar of how the translation of research into the mechanisms of disease can lead to patient benefit. She has received a number of awards including the ADA Outstanding Scientific Achievement Award 2019 and the Dale Medal 2021 (the highest honour awarded by the UK Society of Endocrinology). In 2021, she was elected as a Fellow of the Royal Society in recognition of her exceptional contribution to science.